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MPTA (mesopontine tegmental anesthesia area) acute microinjection procedure


A key node in the neuronal network sub-serving brain-state transitioning
between wake and unconsciousness induced by GABAergic anesthetics injected unilaterally into the brainstem through an indwelling cannula.

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Parasagittal light-sheet image of a rat brain rendered transparent using CLARITY.


Some MPTA projection neurons maintain axons that ascend to synaptic targets in the forebrain, while other axons descend toward terminations in the brainstem and spinal cord. 

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Anesthesia in mice activates discrete populations of neurons throughout the brain.

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Yatziv SL, Yudco O, Vaso K, Mizrahi A, Devor M.
Journal of Neuroscience Research, 2021

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MPTA (mesopontine tegmental anesthesia area) indwelling cannula


X-ray picture of a single microinjection cannula secured to the skull 

MPTA (mesopontine tegmental anesthesia area) acute microinjection procedure


A key node in the neuronal network sub-serving brain-state transitioning
between wake and unconsciousness induced by GABAergic anesthetics injected directly into the brainstem through cannulae.

Freeze fracture images of different neuronal structures


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The Hebrew University

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