Common network for anesthetic induction and sleep-wake regulation
August 18, 2016
The architecture of sleep-wake cycling bear resemblance to the induction and emergence from the general anesthetic state. For this reason, a number of investigators have proposed that general anesthetic agents bring about transitioning from wakefulness to anesthesia by “hijacking” endogenous mechanisms responsible for sleep-wake switching. In this study, we ask whether the mesopontine tegmental anesthesia area (MPTA) - a brainstem node known to be associated with anesthesia, plays a role in sleep-wake regulation. Therefore, we examine effects of axon-sparing lesions in the MPTA on sleep-wake cycling.